Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments
نویسندگان
چکیده
منابع مشابه
Pharmacological inhibitors of glycogen synthase kinase 3.
Three closely related forms of glycogen synthase kinase 3 (GSK-3alpha, GSK-3beta and GSK-3beta2) have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. A large body of evidence supports speculation that pharmacological inhibitors of GSK-3 could be used to...
متن کاملGlycogen Synthase Kinase-3
1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...
متن کاملA CoMFA Study of Glycogen Synthase Kinase 3 Inhibitors
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has recently emerged as a promising target in drug discovery. It is involved in multiple cellular processes and associated with the pathogenesis of several diseases. A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed on a series of GSK3 inhibitors to understand the structu...
متن کاملActivation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in Alzheimer's disease, the most common age-associated dementia, but the mechanism is not understood. Here, we found that activation of GSK-3 by wortmannin or transient overexpression of wild-type GSK-3beta could suppress the induction of long-term potentiation (LTP) in rat hippocampus, whereas simultaneous inhib...
متن کاملexpression of glycogen synthase kinase 3-β (gsk3-β) gene in azoospermic men
background: the wnt/β- the wnt/β-catenin signaling pathway is involved in many developmental processes in both fetal and adult life; its abnormalities can lead to disorders including several types of cancers and malfunction of specific cells and tissues in both animals and humans. its role in reproductive processes has been proven. objective: this study was designed to evaluate the expression o...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2014
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2013.07.010